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脈絡膜新生血管患者與視網膜新生血管患者有不同的血漿一氧化氮及血管內皮新生因子濃度         
脈絡膜新生血管患者與視網膜新生血管患者有不同的血漿一氧化氮及血管內皮新生因子濃度
作者:Fenq-Lih… 文章来源:Department of aOphthalmology and bMedicine, Taipei Veterans General Hospital Taipei, Taiwan 点击数:7187 更新时间:2006/7/11 23:13:40
Because the blood flow is much ampler in choroid than in retina, it is interesting to explore whether choroidal neovascularization (CNV) is more influenced by plasma angiogenic factors than retinal neovascularization. This study is aimed to investigate plasma profiles of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in patients with CNV due to age-related macular degeneration (AMD) and those with retinal neovascularization due to proliferative diabetic retinopathy (PDR). 77 subjects with AMD, 22 PDR, and 42 non-diabetic, non-AMD controls were enrolled in this comparative case series. AMD subjects were classified into three groups: dry type (dry AMD, n=17), wet type with active CNV (CNV/AMD, n=42), and disciform scar due to advanced wet AMD (Scar/AMD, n=18). Plasma VEGF and NO levels of each subject were measured with enzyme-linked immunosorbent assay and chemilluminescence, respectively. Plasma VEGF level in CNV/AMD (median 256.0 pg/ml, interquartile range 146.4-375.3 pg/ml) was significantly higher than in PDR (124.8 pg/ml, 75.7-215.3 pg/ml; P=0.004) and controls (120.3 pg/ml, 82.8-168.2 pg/ml, P 0.001). CNV/AMD also had the highest VEGF level among AMD subgroups. Plasma NO level was significantly elevated in PDR (137.4 μM, 63.7-240.1 μM) when compared with CNV/AMD (71.8 μM, 42.4-113.3 μM; P=0.004) and controls (62.6 μM, 39.0-114.9 μM; P=0.002). There was no significant difference in NO levels among AMD subgroups. No significant correlation between VEGF and NO levels was noted. These findings indicate that both circulating VEGF and NO may play different roles between the pathogenesis of retinal and choroidal neovascularization.
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